The Kratt brothers go around the world looking for animals and use "creature power suits" - suits created by their friend, Aviva, out of the creatures' DNA. There are three villains in the show: Zach Varmitech, who controls the creatures' minds and uses them as slaves; Donita Donata, who freezes creatures and sells them alive as jewelry; and Gourmond, who makes expensive gourmet dishes out of endangered species. The Kratts use their creature powers to foil these three villains' plots.